Coenzyme Models. IX. Micellar Catalysis of Isoalloxazine (Flavin) Oxidation of Dithiol
نویسندگان
چکیده
منابع مشابه
Catalysis of oxidation of nitrogen compounds by flavin coenzymes in the presence of light.
When it was discovered in this laboratory that sarcosine and dimethylglycine are oxidized to formaldehyde by riboflavin phosphate and riboflavin in the absence of protein,1 this observation was pursued, not only because of our interest in the enzymatic oxidation of these substrates, but also because of its implications regarding the origin of biochemical reactions. Subsequent studies to be desc...
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The isomerization of non-native disulfide bonds often limits the rate of protein folding. Small-molecule dithiols can catalyze this process. Here, a symmetric trithiol, tris(2-mercaptoacetamidoethyl)amine, is designed on the basis of criteria known to be important for efficient catalysis of oxidative protein folding. The trithiol is synthesized and attached to two distinct solid supports via on...
متن کاملUnifying concepts in flavin-dependent catalysis.
Flavin-dependent proteins can be involved in a wide variety of biochemical reactions. Among these reactions are electron transfer, oxidase activity, dehydroxygenase activity and mono- and dioxygenations. Furthermore, the oxygenation steps may proceed by either electrophilic or nucleophilic reaction mechanisms. The present paper focuses on aromatic hydroxylation by a nucleophilic C(4a) hydropero...
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The oxidation of alkyl and aryl aldehydes to their corresponding carboxylic acids has been achieved through the action of a biomimetic bridged flavin catalyst. The reaction uses readily available 35% aqueous hydrogen peroxide and is operationally simple. The oxidation is a green and sustainable reaction, obviating chlorinated solvents with minimal byproducts.
متن کاملFlavin Mononucleotide: the Acid-extractable Flavin of the Dpnh-coenzyme Q Reductase of the Respiratory Chain.
Several D P N H dehydrogenases have been purified from heart mitochondria or heart-muscle preparationsl-L STRAUB'S enzym& has been shown by MASSEY 8 to be a form of lipoamide dehydrogenase (EC 1.6.4.3), while the relationship of the remaining preparations to the respiratory chain and to each other is obscure. The flavin extractable by acid t reatment has been reported to be FMN in some casesl, ...
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ژورنال
عنوان ژورنال: Bulletin of the Chemical Society of Japan
سال: 1977
ISSN: 0009-2673,1348-0634
DOI: 10.1246/bcsj.50.2400